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KMID : 0614620120590030232
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Korean Journal of Gastroenterology
2012 Volume.59 No. 3 p.232 ~ p.238
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Could Nafamostat or Gabexate Prevent the Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis?
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Kwon Yong-Hwan
Kim Ji-Yeon
Lee Sang-Jik
Jang Se-Yong
Park Hyun-Woo
Yang Hae-Min
Jung Min-Kyu
Jeon Seong-Woo
Cho Chang-Min
Tak Won-Young
Kweon Young-Oh
Kim Sung-Kook
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Abstract
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Background/Aims ERCP is the most common procedure for the diagnosis and treatment of bile duct and pancreatic disease, but Post-ERCP pancreatitis makes poor outcome in some cases. The protease inhibitors, nafamostat and gabexate, have been used to prevent pancreatitis related to ERCP, but there is some debate. We tried to evaluate the efficacy of gabexate and nafamostat for the prevention of post-ERCP pancreatitis.
Methods: Two hundred forty two patients (73 patients in the gabexate group, 88 patients in the nafamostat group and 81 patients in the placebo group) were included in the study after selective exclusion. The incidence of pancreatitis after ERCP was compared among groups.
Results: The incidence of pancreatitis were 6.8% in the gabexate group, 5.7% in the nafamostat group and 6.2% in the placebo group (p=0.954).
Conclusions: There was no meaningful difference among the gabexate, nafamostat and placebo group.
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KEYWORD
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Endoscopic retrograde cholangiopancreatography, Gabexate, Nafamostat
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